V-Seq HCV is a NGS assay that, in association with V-Seq HCV software, identifies genotypes 1-6 and detects RASs for the subtypes 1a and 1b in Hepatitis C virus as described in the latest HCV guidelines.
HCV Genotypes can respond differently to treatments, therefore HCV genotyping and RASs identification are considered crucial for a personalized therapy. The high rate of HCV genetic variability and the presence of RASs can inhibit the drug activity against target viral proteins (NS3, NS5A, NS5B). Other causes of therapeutic failure are the presence of recombinant genotypes or co-infections, not easily detected by classical genotyping methods.
V-Seq HCV kit contains all the reagents required for the target amplification and in association with the accessory kits generates NGS libraries compatible with the Illumina systems.
NS3, NS5A and NS5B are the target of the new antiviral drugs and the genes where the majority of RASs are localized.
V-Seq HCV kit identifies genotypes and subtypes assessing the variability of 5’UTR, CORE and NS5B regions. The kit detects RASs for genotypes 1a and 1b through the analysis of NS3, NS5A and NS5B regions.
V-Seq HCV Software is a proprietary software for bioinformatics analysis of sequencing results.
Key features:
• Report including sample genotype/subtype, depth and percentage of coverage for each target region; RASs based on the latest guidelines and additional mutations for genotype 1a and 1b
• Results confirmation supported by a phylogenetic analysis
• Database for samples data storage
• Automated and user friendly data analysis
• Different user levels
HCV Genotypes can respond differently to treatments, therefore HCV genotyping and RASs identification are considered crucial for a personalized therapy. The high rate of HCV genetic variability and the presence of RASs can inhibit the drug activity against target viral proteins (NS3, NS5A, NS5B). Other causes of therapeutic failure are the presence of recombinant genotypes or co-infections, not easily detected by classical genotyping methods.
V-Seq HCV kit contains all the reagents required for the target amplification and in association with the accessory kits generates NGS libraries compatible with the Illumina systems.
NS3, NS5A and NS5B are the target of the new antiviral drugs and the genes where the majority of RASs are localized.
V-Seq HCV kit identifies genotypes and subtypes assessing the variability of 5’UTR, CORE and NS5B regions. The kit detects RASs for genotypes 1a and 1b through the analysis of NS3, NS5A and NS5B regions.
V-Seq HCV Software is a proprietary software for bioinformatics analysis of sequencing results.
Key features:
• Report including sample genotype/subtype, depth and percentage of coverage for each target region; RASs based on the latest guidelines and additional mutations for genotype 1a and 1b
• Results confirmation supported by a phylogenetic analysis
• Database for samples data storage
• Automated and user friendly data analysis
• Different user levels